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Total 19267 results found since Jan 2013.

Co-medications and drug-drug interactions in people living with HIV in Turkey in the era of integrase inhibitors.
CONCLUSION: Results suggested the need for attention about co-medication in PLWH regardless of whether they are young or older. CNS drugs should be questioned more detailed in MSM, as well as CVS drugs in older HS patients. Elvitegravir/cobicistat is significantly associated with DDIs and switching to an unboosted INSTI should be considered in patients with multiple comorbidities. PMID: 32787762 [PubMed - as supplied by publisher]
Source: Current HIV Research - August 11, 2020 Category: Infectious Diseases Authors: Yeşilbağ Z, Şengül Eİ, Şenoğlu S, Aydın ÖA, Karaosmanoğlu HK Tags: Curr HIV Res Source Type: research

Clinical outcomes after IL-6 blockade in patients with COVID-19 and HIV: a case series
CONCLUSIONS: In this case series of hospitalized PWH with COVID-19 and given IL-6ri prior to the common use of corticosteroids, there are reports of secondary or co-infection in severely ill patients. Comprehensive studies in PWH, particularly with CD4 counts < 200 cells, are warranted to assess infectious and other outcomes after IL-6ri use, particularly in the context of co-administered corticosteroids.PMID:35148782 | DOI:10.1186/s12981-022-00430-x
Source: AIDS Research and Therapy - February 12, 2022 Category: Infectious Diseases Authors: Samuel J Minkove Grant Geiger Josep M Llibre Mary W Montgomery Natalie E West Natasha M Chida Annukka A R Antar Dima Dandachi Ethel D Weld HIV-COVID-19 Consortium Source Type: research

A comparative study of CIDP in a cohort of HIV-infected and HIV-uninfected patients
Conclusion: This study shows that HIV-infected patients with CIDP were younger, were more often female, displayed a monophasic progressive course, were highly steroid-responsive, and went into remission within 12 months of corticosteroid initiation.
Source: Neurology Neuroimmunology and Neuroinflammation - December 14, 2016 Category: Neurology Authors: Moodley, K., Bill, P. L. A., Patel, V. B. Tags: HIV, Peripheral neuropathy Article Source Type: research

Immune responses to HIV and vaccination
Abstract: The interaction between HIV and the immune system determines both the extent to which immunity controls HIV, delaying disease progression, and the way in which HIV causes disease by depleting CD4 T-cell populations. The way in which some individuals progress rapidly, whilst others become long-term non-progressors, is largely explained by how well the immune system controls the virus. After initiating anti-retroviral treatment, immune responses may become dysregulated, causing immune reconstitution inflammatory syndrome (IRIS) which may present either as the unmasking of an undiagnosed latent infection, or as para...
Source: Medicine - August 1, 2013 Category: Internal Medicine Authors: Derek C. Macallan Tags: Fundamentals of HIV Source Type: research

Outcomes of Stevens –Johnson syndrome and toxic epidermal necrolysis in HIV-infected patients when using systemic steroids and/or intravenous immunoglobulins in Pietermaritzburg, South Africa
Conclusion: HIV-infected SJS and TEN patients were treated in a tertiary dermatology ward with a treatment plan of skin care, and a combination of systemic corticosteroids and IVIG respectively had a survival rate of 97%.
Source: Southern African Journal of HIV Medicine - July 3, 2019 Category: African Health Authors: Antoinette V. Chateau Source Type: research

Motor lumbosacral radiculopathy in HIV-infected patients
Conclusion: HIV-infected patients with motor lumbosacral radiculopathy responded to corticosteroids, with no relapses during the 18-month follow-up period.
Source: Southern African Journal of HIV Medicine - October 27, 2019 Category: African Health Authors: Kaminie Moodley Source Type: research

Inhaled Steroids in HIV+ Patients on Protease InhibitorsInhaled Steroids in HIV+ Patients on Protease Inhibitors
What are the pharmacokinetic and clinical issues for HIV-positive patients requiring treatment with inhaled corticosteroids while on protease inhibitors? HIV Medicine
Source: Medscape Today Headlines - October 14, 2013 Category: Consumer Health News Tags: HIV/AIDS Journal Article Source Type: news

New insights into immune reconstitution inflammatory syndrome of the central nervous system
Purpose of review: To highlight the importance of immune reconstitution inflammatory syndrome affecting the brain in HIV-infected individuals in the absence of opportunistic infections. To describe the varied clinical manifestations, unifying pathophysiological features and discuss the principles of management of this syndrome. Recent findings: Immune reconstitution inflammatory syndrome within the brain is commonly seen in patients with HIV infection upon initiation of antiretroviral drugs. The fulminant forms occur in the face of opportunistic infections or uncontrolled viral replication within the brain. In this case, t...
Source: Current Opinion in HIV and AIDS - October 6, 2014 Category: Infectious Diseases Tags: HIV NEUROLOGY: Edited by Christopher Power and Bruce J. Brew Source Type: research

A case of a drug reaction to sulfasalazine in a patient infected with HIV
Conclusion: In conclusion, it is important to consider drug reactions when evaluating patients infected with HIV.
Source: Southern African Journal of HIV Medicine - December 3, 2018 Category: African Health Authors: Leanne Swart Source Type: research

Ritonavir and Topical Ocular Corticosteroid Induced Cushing’s Syndrome in an Adolescent With HIV-1 Infection
We describe a case of symptomatic Cushing’s syndrome in an adolescent male with sight-threatening vernal keratoconjunctivitis on antiretroviral therapy for HIV-1 infection that included ritonavir, a potent cytochrome p450 CYP3A4 inhibitor. CYP3A4 inhibition reduces the metabolism of exogenous corticosteroids leading to suppression of endogenous steroid production and Cushing’s syndrome.
Source: The Pediatric Infectious Disease Journal - April 14, 2017 Category: Infectious Diseases Tags: HIV Reports Source Type: research

The tuberculosis-associated immune reconstitution inflammatory syndrome: recent advances in clinical and pathogenesis research
Purpose of review Antiretroviral therapy (ART) is an essential, life-saving intervention for HIV infection. However, ART initiation is frequently complicated by the tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) in TB endemic settings. Here, we summarize the current understanding highlighting the recent evidence. Recent findings The incidence of paradoxical TB-IRIS is estimated at 18% (95% CI 16–21%), higher than previously reported and may be over 50% in high-risk groups. Early ART initiation in TB patients increases TB-IRIS risk by greater than two-fold, but is critical in TB patient...
Source: Current Opinion in HIV and AIDS - October 9, 2018 Category: Infectious Diseases Tags: TUBERCULOSIS AND HIV: Edited by Richard E. Chaisson and Haileyesus Getahun Source Type: research

Immune response to Leishmania antigens in an AIDS patient with mucocutaneous leishmaniasis as a manifestation of immune reconstitution inflammatory syndrome (IRIS): a case report
Conclusion: The results suggest that the production of inflammatory cytokines by unstimulated T-lymphocytes could contribute to occurrence of leishmaniasis associated with IRIS.
Source: BMC Infectious Diseases - February 3, 2015 Category: Infectious Diseases Authors: Luana GoisRoberto BadaróRobert SchooleyMaria Grassi Source Type: research

HIV-associated obstructive lung diseases: insights and implications for the clinician.
Abstract The effectiveness of antiretroviral therapy to control HIV infection has led to the emergence of an older HIV population who are at risk of chronic diseases. Through a comprehensive search of major databases, this Review summarises information about the associations between chronic obstructive pulmonary disease (COPD), asthma, and HIV infection. Asthma and COPD are more prevalent in HIV-infected populations; 16-20% of individuals with HIV infection have asthma or COPD, and poorly controlled HIV infection worsens spirometric and diffusing capacity measurements, and accelerates lung function decline by abou...
Source: Respiratory Care - May 13, 2014 Category: Respiratory Medicine Authors: Drummond MB, Kirk GD Tags: Lancet Respir Med Source Type: research